Pharmacology: Flunarizine is the derivative of cinnarizine which has antihistamine and selective calcium channel-blocking activities.
Pharmacokinetics: Flunarizine is well-absorbed from the gastrointestinal tract, reaching peak plasma concentration within 2-4 hrs after oral administration. After extensive hepatic metabolism, flunarizine and its metabolites are excreted through the faeces via the bile. The mean terminal elimination half-life is about 18 days. Plasma protein-binding is 90%.