Severe obesity, history of resp impairment or sleep apnea or unidentified resp infection. Myositis. Relapse of malignancy of a malignant disease, DM, hypothyroidism during GH treatment, endocrine disorders, including GH deficiency. Excessive glucocorticoid therapy will inhibit the growth promoting effect of human growth hormone. Patients w/ coexisting ACTH deficiency should have their glucocorticoid replacement dose carefully adjusted to avoid an inhibitory effect on growth. Pregnancy & lactation.