Initially 1 tab of 500 mg once daily, may be adjusted based on blood glucose measurements after 10-15 days. Max: 2,000 mg once daily. If glycaemic control is not achieved on 2,000 mg once daily, consider Glucophage XR 1,000 mg twice daily. If glycaemic control is still not achieved, may be switched to metformin tab IR up to max: 3,000 mg daily. Patient already treated w/ metformin
Initially same daily dose of metformin IR tab. Transfer from another oral antidiabetic agent
Discontinue other agent & initiate as indicated. Combination w/ insulin
Initially 500 once daily, adjust insulin based on blood glucose measurements. Patient w/ CrCl or GFR 45-59 mL/min
Initially 500 mg or 750 mg once daily. Max: 1,000 mg daily, CrCl or GFR 30-44 mL/min
Max: 1,000 mg daily.