Granon Tablet

Granon Tablet Mechanism of Action



Dexa Medica
Full Prescribing Info
The 5-HT3 type serotonin receptor is located peripherally in the vagus nerve terminal and is central to the chemoreceptor trigger zone in the postrema area. During the process of chemotherapy that induces vomiting, enterochromaffin mucous cells release serotonin, where serotonin will stimulate the 5-HT3 receptor and activate the vagus afferent which then induces vomiting.
Granisetron is a potent antiemetic and is a very selective antagonist of the 5-hydroxytryptamine (5-HT) receptor 3. Granisetron has a very small (negligible) affinity for other types of receptors including 5-HT and on the dopamine D2 bond side.
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