Granisetron may reduce intestinal motility, so patients with signs of acute intestinal obstruction must be monitored after administration of granisetron.
Cross sensitivity between 5-HT3 antagonists has been reported. GRANON film-coated tablets are not recommended for patients with rare hereditary problems including galactose intolerance, lactase deficiency, or glucose-galactose malabsorption.
Like the other 5-HT3 antagonists, cases of serotonin syndrome (including changes in mental status, autonomic dysfunction and neuromuscular abnormalities) have been reported to occur after joint use between granisetron and other serotonergic drugs. If concomitant use between granisetron and other serotonergic drugs is clinically needed, it is recommended to monitor the patients' condition closely.
Pregnancy and lactation.