Guselkumab - subcutaneous


Patient Medicine Information
Why do I need this medicine?
Guselkumab is used to treat moderate to severe plaque psoriasis (a type of skin disease that allows the skin cells to rapidly build up causing itchy patches of thick, red skin and silvery scales).
How do I use this medicine?
Your doctor or nurse will administer the injection for you. If you or your caregiver had been given the proper training on the preparation and injection techniques of Guselkumab, you or your caregiver may do the administration.

Use this medicine exactly as directed by your doctor or according to the instructions on the label. Do not administer more or less than instructed by your doctor.

Guselkumab is to be injected subcutaneously (into the fatty layer under the skin, usually in the thigh, upper arm or abdomen area).

Remember to rotate the injection sites. Do not inject into the same area all the time. New injection sites should be at least 1.5 inches away from the previous injection site. Do not inject at least 2 inches around the navel (belly button), into areas where the skin is tender, bruised, red, hard, thick, scaly or affected by psoriasis.

This medicine is available as a single-use pre-filled pen or syringe. Make sure you know how to use the specific device you have been given. If you have problems or do not understand the instructions, ask your doctor or pharmacist.

To use the pre-filled injection pen, follow these steps:
  1. Prepare the injection pen as instructed by your doctor or nurse.
  2. Wash your hands thoroughly with soap and warm water.
  3. Swab the injection site area with alcohol and allow to dry.
  4. Twist and pull off the bottom cap of the injection pen. Ensure to keep your hands away from the needle guard after the cap is removed. Do not shake the pen.
  5. Hold the handle of the injection pen with your hand and place its needle end straight onto the skin of the injection site.
  6. Push the handle straight down to release the medicine. Continue pushing the handle all the way down until you hear a clicking sound and the green body of the injection pen is no longer visible to get a full dose. Do not lift the pre-filled pen during injection.
  7. After administering your full dose, lift the injection pen straight up. You will see a yellow band indicating the needle guard is locked and the pen can no longer be used.
  8. Press a cotton ball or gauze pad on the injection site to stop any bleeding. Do not rub on it. You may also cover the injection site with a bandage if needed.
  9. Throw the pen according to your doctor or pharmacist’s instructions. Do not throw away in household trash.
To use the pre-filled injection syringe, follow these steps:
  1. Prepare the injection syringe as instructed by your doctor or nurse.
  2. Wash your hands thoroughly with soap and warm water.
  3. Swab the injection site area with alcohol and allow to dry.
  4. Hold the pre-filled syringe in the middle of its body and keep your hand away from the plunger. Do not shake the syringe. Pull off the needle cap when you are ready to inject.
  5. Gently pinch the skin at the injection site using your other hand. Hold the syringe like a pencil and insert the needle into the pinched skin at 45-degree angle (slight angle) using a quick dart-like motion.
  6. Slowly press the plunger all the way down until the syringe is empty.
  7. Release the pressure from the plunger. The safety guard will cover the needle and lock into place which automatically retracts the needle from your skin.
  8. Press a cotton ball or gauze pad over the injection site to stop any bleeding. Do not rub on it. You may also cover the injection site with a bandage if needed.
  9. Dispose your used pre-filled syringes according to your doctor or pharmacist’s instructions. Do not throw away in the household trash.
The dose of this medicine will be decided by your doctor. Your doctor will advise you on the course of the treatment depending on your condition and response to the medication.

Guselkumab must be administered regularly for it to be effective. Continue using this medicine even when you feel better. Do not stop using it unless instructed by the doctor.
What should I do if I have forgotten to use this medicine?
Ensure that you keep all appointments with your doctor so that you do not miss any doses. Your doctor also needs to regularly monitor your response to Guselkumab.

If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.

DO NOT double a dose under any circumstances.

If you often forget to use your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Do not use Guselkumab if you ever had an allergic reaction (e.g. rashes, breathlessness, swollen eyes) to this medicine or any similar medicines.

Alert your doctor if you have an active infection (e.g. tuberculosis or TB, blood infection, hepatitis B), as Guselkumab may not be suitable for you.

You must avoid any vaccinations without consulting with your doctor. Alert your doctor if you have been recently vaccinated or if you are planning to get vaccinated.
What should I take note of while using this medicine?
Inform your doctor if you have the following conditions:
  • history of long-term or recurring infections
  • history of TB
Let your doctor know if you are pregnant or breastfeeding.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • Your doctor may conduct a screening test for TB prior to and periodically during your treatment with this medicine.
  • Regular monitoring of signs and symptoms of infection and TB may be needed while you are being treated with Guselkumab.
What side effects could I experience?
Guselkumab may cause any of the following side effects: headache, migraine, diarrhoea, sore throat, common cold, mouth sores, stomach flu, fungal infection of the skin, joint pain, and skin redness or pain at injection sites.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • signs of allergic reaction e.g. hives, rashes, breathlessness, swollen eyes, mouth or throat
  • signs of infection e.g. fever, flu-like symptoms, muscle aches, unusual tiredness
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I use this with other medicines?
Avoid vaccinations during treatment with Guselkumab. Alert your doctor if you have been recently vaccinated or if you are planning to get vaccinated.

Inform your doctor and pharmacist if you are using medicines used in organ transplant or certain immune disorders such as belimumab and infliximab.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in the refrigerator, between 2-8°C, away from the reach of children.

Do not freeze Guselkumab, otherwise, it will no longer be effective and should not be used.

Protect from light.

Do not use this medicine if it becomes cloudy or if it has changed in colour.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on guselkumab - subcutaneous and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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