Imodium

Imodium

loperamide

Manufacturer:

Johnson & Johnson
Concise Prescribing Info
Contents
Loperamide HCl
Indications/Uses
Control & symptomatic relief of acute non-specific diarrhea. Chronic diarrhea associated w/ inflammatory bowel disease. Reduction of vol of discharge from ileostomies in adult patients ≥18 yr.
Dosage/Direction for Use
Acute diarrhea Initial dose: 4 mg, followed by 2 mg after each unformed stool. Max daily dose: 16 mg. Chronic diarrhea Initial dose: 4 mg, followed by 2 mg after each unformed stool until diarrhea is controlled. Ave daily maintenance dose: 2-12 mg. Max daily dose: 16 mg.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Abdominal pain in the absence of diarrhea. Primary therapy in patients w/ acute dysentery characterized by blood in the stool & high fever; acute ulcerative colitis; bacterial enterocolitis caused by invasive organisms eg, Salmonella, Shigella, Campylobacter; pseudomembranous colitis associated w/ the use of broad-spectrum antibiotics. Peristaltic resistance. Constipation, abdominal distension or presence of signs of ileus. Infant <24 mth.
Special Precautions
Discontinue therapy if the patient develops constipation; in AIDS patients in the occurrence of abdominal swelling or distension; if diarrhea has not improved after 48 hr of treatment. Ask physician about the need for fluid & electrolyte replacement. Do not drive or operate machinery. Reduced liver function. Not to be used during pregnancy unless the benefits outweigh the risks. Lactation.
Adverse Reactions
Rash, pruritus, urticaria, angioedema, bullous eruption eg, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis; allergic reactions, severe hypersensitivity reactions eg, anaphylactic shock & anaphylactoid reactions; dry mouth, abdominal pain, distension or discomfort, upper abdominal pain, nausea, vomiting, flatulence, dyspepsia, constipation, paralytic ileus, megacolon including toxic megacolon, glossodynia; urinary retention; drowsiness, dizziness, abnormal coordination, depressed level of consciousness, hypertonia, decreased consciousness, stupor; miosis; fatigue.
Drug Interactions
Increased systemic exposure w/ CYP3A4 inhibitors eg, itraconazole, CYP2C8 inhibitors eg, gemfibrozil or P-gp inhibitors eg, quinidine, ritonavir. Decreased systemic exposure of saquinavir.
MIMS Class
ATC Classification
A07DA03 - loperamide ; Belongs to the class of antipropulsives. Used in the treatment of diarrhea.
Presentation/Packing
Form
Imodium FC tab 2 mg
Packing/Price
10 × 10's (Rp729,560/boks)
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