Indigo carmine

Generic Medicine Info
Indications and Dosage
Marker dye in urological procedures
Adult: 40 mg preferably via slow IV inj. May also be given via IM inj.
Uncontrolled heart failure, history of allergic reactions, haemodynamic instability.
Special Precautions
Patient with heart rate and conduction disorders, hypertension, coronary disorders. Pregnancy and lactation.
Adverse Reactions
Significant: Idiosyncratic reactions (e.g. rash, pruritus bronchoconstriction), paradoxical pressor effects.
Cardiac disorders: Bradycardia.
Gastrointestinal disorders: Nausea, vomiting.
Skin and subcutaneous tissue disorders: Skin discoloration (large doses in children and underweight patients).
Vascular disorders: Hypertension.
IM/IV/Parenteral: C
Symptoms: Hypertensive crisis and severe bradycardia. Management: May administer peripheral vasodilators.
Lab Interference
May interfere with colorimetric methods of urinalysis.
Mechanism of Action: Indigo carmine is a marker dye which retains its blue colour during passage through the body. It is used in the test of renal function.arker 
Excretion: Via urine. Elimination half-life: 4-5 minutes (IV).
Chemical Structure

Chemical Structure Image
Indigo carmine

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 2723854, Indigo carmine. Accessed Sept. 25, 2020.

Store between 15-30°C. Protect from light.
MIMS Class
Radiographic & Diagnostic Agents
ATC Classification
V04CH02 - indigo carmine ; Belongs to the class of diagnostic agents used to test for renal function.
Anon. Indigotindisulfonate Sodium. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. Accessed 16/07/2020.

Anon. Indigotinedisulfonate. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. Accessed 16/07/2020.

Buckingham R (ed). Indigo Carmine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 16/07/2020.

Indigo Carmine 40 mg/5 mL Solution for Injection (SERB S.A.). MHRA. Accessed 16/07/2020.

Indigo Carmine Injection, Solution (American Regent, Inc.). DailyMed. Source: U.S. National Library of Medicine. Accessed 16/07/2020.

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