Pharmacokinetic Interactions: Beclometasone dipropionate undergoes a very rapid metabolism via esterase enzymes without involvement of CYP450 system.
Pharmacodynamic Interactions: β-blockers (including eye drops) should be avoided in asthmatic patients. If β-blockers are administered for compelling reasons, the effect of formoterol will be reduced or abolished.
On the other hand, concomitant use of other β-adrenergic drugs can have potentially additive effects therefore, caution is required when theophylline or other β-adrenergic drugs are prescribed concomitantly with formoterol.
Concomitant treatment with quinidine, disopyramide, procainamide, phenothiazines, antihistamines, monoamine oxidase inhibitors and tricyclic antidepressants can prolong the QTc-interval and increase the risk of ventricular arrhythmias.
In addition L-dopa, L-thyroxine, oxytocin and alcohol can impair cardiac tolerance towards β2-sympathomimetics. Concomitant treatment with monoamine oxidase inhibitors including agents with similar properties eg, furazolidone and procarbazine may precipitate hypertensive reactions.
There is an elevated risk of arrhythmias in patients receiving concomitant anaesthesia with halogenated hydrocarbons.
Concomitant treatment with xanthine derivatives, steroids or diuretics may potentiate a possible hypokalaemic effect of β2-agonists. Hypokalaemia may increase the disposition towards arrhythmias in patients who are treated with digitalis glycosides.
Innovair contains a small amount of ethanol. There is a theoretical potential for interaction in particularly sensitive patients taking disulfiram or metronidazole.
Incompatibilities: Not applicable.