Instructions for Use and Handling and Disposal: Administer once every 3 months. Shake syringe vigorously for at least 15 seconds.
For intramuscular injection only.
Do not administer by any other route.
Important: INVEGA TRINZA should be administered by a healthcare professional as a single injection. Do not divide dose into multiple injections.
INVEGA TRINZA is intended for intramuscular use only. Inject slowly, deep into the muscle taking care to avoid injection into a blood vessel.
Read complete instructions prior to use.
Dosing: This medication should be administered once every 3 months.
Preparation: Peel off tab label from the syringe and place in patient record.
INVEGA TRINZA requires longer and more vigorous shaking than the 1-month paliperidone palmitate injectable product.
Shake the syringe vigorously, with the syringe tip pointing up, for at least 15 seconds within 5 minutes prior to administration (see Step 2).
Thin Wall Safety: Needle Selection: Thin wall safety needles are designed to be used with INVEGA TRINZA. Therefore, it is important to only use the needles provided in the INVEGA TRINZA kit.
1. Select needle: Needle selection is determined by injection area and patient weight.
2. Prepare for injection: SHAKE VIGOROUSLY for at least 15 seconds.
With the syringe tip pointing up, SHAKE VIGOROUSLY with a loose wrist for at least 15 seconds to ensure a homogeneous suspension.
NOTE: This medication requires longer and more vigorous shaking than the 1-month paliperidone palmitate injectable product.
Proceed to the next step immediately after shaking. If more than 5 minutes pass before injection, shake vigorously with the syringe tip pointing up again for at least 15 seconds to re-suspend the medication.
Check suspension: After shaking the syringe for 15 seconds, check the liquid in the viewing window. The suspension should appear uniform and milky white in color.
It is also normal to see small air bubbles.
Open needle pouch and remove cap: First, open needle pouch by peeling the cover back half way. Place on a clean surface. Then, holding the syringe upright, twist and pull the rubber cap to remove.
Grasp needle pouch: Fold back needle cover and plastic tray. Then, firmly grasp the needle sheath through the pouch
Attach needle: With the other hand, hold the syringe by the luer connection and attach it to the safety needle with a gentle clockwise twisting motion. Do not remove the pouch until the syringe and needle are securely attached.
Remove needle sheath: Pull the needle sheath away from the needle in a stiaight motion. Do not twist the sheath, as this may loosen the needle from the syringe.
Remove air bubbles: Hold the syringe upright and tap gently to make any air bubbles rise to the top. Remove air by pressing the plunger rod upward carefully until a drop of liquid comes out of the needle tip.
3. Inject: Inject dose: Slowly inject the entire contents of the syringe intramuscularly, deep into the selected deltoid or gluteal muscle. Do not administer by any other route.
4. After injection: Secure needle: After the injection is complete, use the thumb or a flat surface to secure the needle in the safety device. The needle is secure when a "click" sound is heard.
Dispose properly: Dispose of the syringe and unused needle in an approved sharps container.
Thin wall safety needles are designed specifically for use with INVEGA TRINZA. Unused needle should be discarded and not saved for future use.
Incompatibilities: INVEGA TRINZA should not be mixed with any other product or diluent and is intended for intramuscular administration directly from the syringe in which it is packaged.