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Indications and Dosage
Oral
Disorders associated with reduced gastrointestinal motility Adult: 50 mg tid. May reduce dose depending on the patient’s age and symptoms.
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Contraindications
GI haemorrhage, mechanical obstruction or perforation, Parkinson’s disease.
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Special Precautions
Hepatic and renal impairment. Pregnancy and lactation.
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Adverse Reactions
Diarrhoea, abdominal pain, constipation, headache, dizziness, nausea, increased salivation, leucopenia, thrombocytopenia, tremor, rash, redness and itching, anaphylactoid reactions, gynaecomastia, increased prolactin, AST and ALT, jaundice.
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Drug Interactions
May reduce the effect w/ anticholinergic drugs.
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Action
Description: Itopride increases acetylcholine concentrations by inhibiting dopamine D2 receptors and acetylcholinesterase, resulting in enhancement of GI motility.
Pharmacokinetics: Absorption: Rapidly and almost completely absorbed from the GI tract. Bioavailability: 60%. Time to peak plasma concentration: 0.5-0.75 hr. Distribution: Plasma protein binding: Approx 96%, mainly to albumin. Metabolism: Undergoes extensive hepatic metabolism. Excretion: Via urine. Terminal half-life: Approx 6 hr. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Database. Itopride, CID=3792, https://pubchem.ncbi.nlm.nih.gov/compound/Itopride (accessed on Jan. 21, 2020) |
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Storage
Store between 15-30°C.
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ATC Classification
A03FA07 - itopride ; Belongs to the class of propulsives. Used in the treatment of functional gastrointestinal disorders.
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References
Anon. Itopride. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 18/01/2016. Buckingham R (ed). Itopride Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 18/01/2016. Ganaton. MIMS Philippines. http://www.mims.com/philippines. Accessed 18/01/2016.
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