Pharmacology: Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory and antipyretic action. As NSAID, ketoprofen has been shown to have inhibitory effect on prostaglandin synthesis.
Gel: Only a small amount of ketoprofen is absorbed following topical application.
Pharmacokinetics: Kaltrofen tablet is rapidly and completely absorbed from the gastrointestinal tract. When ketoprofen is administered with food, its total bioavailability is not altered; however, the rate of absorption from either dosage form is slowed. Plasma peak levels are reached in ½-2 hrs. In elderly patients, plasma elimination half-life is 5 hrs and 3 hrs in adult patients.
Kaltrofen OD is designed to release the drug at a controlled rate, in the pH environment in the small intestine. The plasma half-life is 5-12 hrs for the slow-release preparation. Peak plasma levels are usually reached 6-7 hrs after dosing. Kaltrofen OD is not recommended for treatment of acute pain because of its controlled-release characteristic.
Suppositories administered late at night provide more effective control of overnight symptom than oral medication. Plasma peak levels are reached in 1-2 hrs, with plasma elimination half-life ranging from 2-3 hrs.
Kaltrofen is well absorbed from the IM route.