Elderly (≥65 Years): Adjustment of the dose is recommended in elderly patients with compromised renal function (see Renal Impairment as follows).
Children: There are insufficient data to recommend the use of levetiracetam in children and adolescents <16 years.
Renal Impairment: The daily dose must be individualised according to renal function. Refer to the table provided and adjust the dose as indicated. To use the dosing table, an estimate of the patient's creatinine clearance (CrCl) in mL/min is needed. (See table.) The CrCl in
Hepatic Impairment: No dose adjustment is needed in patients with mild to moderate hepatic impairment. In patients with severe hepatic impairment, the creatinine clearance may underestimate the renal insufficiency. Therefore, a 50% reduction of the daily maintenance dose is recommended when the CrCl is <70 mL/min.
Administration: Keppra tablets must be taken orally, swallowed with a sufficient quantity of liquid and may be taken with or without food.
The daily dose is administered in 2 equally divided doses.