Epilepsy Adult >12 yr Monotherapy 25 mg once daily for 2 wk, then 50 mg once daily for 2 wk; maintenance: 100-200 mg (once daily or 2 divided doses). Increase dose by 50-100 mg every 1-2 wk.
Add-on therapy w/ Na valproate 12.5 mg (25 mg alternate days) for 2 wk, then 25 mg once daily for 2 wk; maintenance: 100-200 mg/day once daily or in 2 divided doses. Increase dose by 25-50 mg every 1-2 wk.
Add-on therapy w/ phenytoin, carbamazepine, primidone & phenobarb 50 mg once daily for 2 wk, then 100 mg/day in 2 divided doses for 2 wk; maintenance: 200-400 mg/day in 2 divided doses. Increase dose by 100 mg every 1-2 wk.
Add-on therapy w/ drugs that do not significantly inhibit or induce lamotrigine glucuronidation 25 mg once daily for 2 wk, then 50 mg once daily for 2 wk; maintenance: 100-200 mg once daily or in 2 divided doses. Increase dose by 50-100 mg every 1-2 wk.
Childn 2-12 yr Add-on therapy w/ Na valproate 0.15 mg/kg/day once daily for 2 wk, followed by 0.3 mg/kg/day once daily for 2 wk. May be increased by 0.3 mg/kg increments every 1-2 wk to achieve a maintenance dose of 1-5 mg/kg (once daily or 2 divided doses) to max 200 mg/day.
Add-on therapy w/ phenytoin, carbamazepine, primidone & phenobarb 0.6 mg/kg/day once daily for 2 wk, followed by 1.2 mg/kg/day once daily for 2 wk. May be increased by 1.2 mg/kg increments every 1-2 wk to achieve a maintenance dose of 5-15 mg/kg (once a day or 2 divided doses) to max 400 mg/day.
Add-on therapy w/ drugs that do not significantly inhibit or induce lamotrigine glucuronidation 0.3 mg/kg, then 0.6 mg/kg. To be given in 1 or 2 divided doses for 2 wk. May be increased by 0.6 mg/kg increments every 1-2 wk to achieve a maintenance dose of 1-10 mg/kg (once daily or 2 divided doses) to max 200 mg/day.
Bipolar Adult >18 yr Adjunct therapy w/ Na valproate 12.5 mg (25 mg alternate days) for 2 wk, then 25 mg once daily for 2 wk, then 50 mg once daily or 2 divided doses for 1 wk; target stabilization: 100-200 mg once daily or 2 divided doses.
Adjunct therapy w/ phenytoin, carbamazepine, phenobarb, primidone 50 mg once daily for 2 wk, then 100 mg in 2 divided doses for 2 wk, then 200 mg in 2 divided doses for 1 wk; target stabilization: 300-400 mg/day in 2 divided doses.
Monotherapy or adjunct therapy w/ drugs that do not significantly inhibit or induce lamotrigine glucuronidation 25 mg once daily for 2 wk, then 50 mg once daily or 2 divided doses for 2 wk, then 100 mg once daily or 2 divided doses for 1 wk; target stabilization: 200 mg once daily or 2 divided doses for 1 wk.
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