Daily dose is administered in 2 equally divided doses.
Adult & adolescent ≥16 yr Initially 500 mg twice daily, may be increased up to 1,500 mg twice daily. Dose changes can be made in 500 mg twice daily increments or decrements every 2-4 wk.
Patient w/ renal impairment CrCl >80 mL/min 500-1,500 mg twice daily,
50-79 mL/min 500-1,000 mg twice daily,
30-49 mL/min 250-750 mg twice daily,
<30 mL/min 250-500 mg twice daily.
ESRD patient undergoing dialysis 750 mg loading dose on 1st day, then 500-1,000 mg once daily. Followed by 250-500 mg supplemental dose after dialysis.