Daily dose is administered in 2 equally divided doses. Adult & adolescent ≥16 yr
Initially 500 mg twice daily, may be increased up to 1,500 mg twice daily. Dose changes can be made in 500 mg twice daily increments or decrements every 2-4 wk. Patient w/ renal impairment CrCl >80 mL/min
500-1,500 mg twice daily, 50-79 mL/min
500-1,000 mg twice daily, 30-49 mL/min
250-750 mg twice daily, <30 mL/min
250-500 mg twice daily. End-stage renal disease patient undergoing dialysis
750 mg loading dose on 1st day, then 500-1,000 mg once daily. Followed by 250-500 mg supplemental dose after dialysis.