Lodoz is well-tolerated, its side effects are for the most part attributable to its pharmacological activity.
The side effects reported for each individual constituent are as follows: Bisoprolol: Clinical:
Occasionally, the following side effects are reported: Central nervous disturbances eg, tiredness, depression, dizziness, headache, asthenia, sensation of cold extremities, bradycardia, insomnia, nightmares, digestive complaints (gastralgia, nausea, vomiting), muscle and joint ache, perspiration.
In rare cases, the following have been reported: Decrease in atrioventricular conduction or intensification of existing atrioventricular block, exacerbation of heart failure, sudden fall in blood pressure, bronchospasm, aggravation of existing intermittent claudication, paresthesia, various skin manifestations, including psoriasis, lacrimation abnormality.
Hypersensitivity reactions, anaphylactic reactions, essentially dermatological, in patients predisposed to allergic or asthmatic manifestations: Nausea, constipation, vertigo, asthenia, paresthesia, headache, rarely reported and usually requiring dose reduction; exceptional cases of pancreatitis.
Although the risk of hypokalemia is limited with this combination because of the very low dose of hydrochlorothiazide, serum electrolytes should be checked at regular intervals to detect any signs of water and electrolyte imbalance: Hyponatremia, hypochloremic alkalosis and hypokalemia.
Hypokalemia may occur, especially after administration of corticoids, tetracosactide or laxatives.
An increase in serum uric acid and blood glucose during treatment: The use of this diuretic in patients predisposed to gout or in diabetics should be carefully considered. Hematological disorders have been very rare, thrombocytopenia, leukopenia, agranulocytosis.