Lonazolac


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Pain and inflammation Up to 600 mg/day in divided doses Rectal Pain and inflammation 400 mg twice daily.
Dosage Details
Oral
Pain and inflammation
Adult: Up to 600 mg daily in divided doses.

Rectal
Pain and inflammation
Adult: 400 mg bid.
Contraindications
Hypersensitivity to NSAIDs or aspirin. Acute gastric ulcer.
Special Precautions
Infections, asthma, allergic disorders, haemorrhagic disorders, hypertension. Elderly. Hepatic, renal and CV impairment.
Adverse Reactions
Nausea, stomach discomfort, headache, dizziness, allergic skin reactions.
Drug Interactions
Enhanced effects of oral anticoagulants, phenytoin and sulfonylureas. Increased plasma levels of lithium, methotrexate and cardiac glycosides. Increased risk of nephrotoxicity with ACE inhibitors, ciclosporin, tacrolimus or diuretics. Increased risk of hyperkalaemia with ACE inhibitors and potassium-sparing diuretics. Reduced antihypertensive effects of ACE inhibitors, β-blockers and diuretics. Convulsions may occur when used with quinolones. Increased risk of adverse effects with other NSAIDs. Increased risk of GI bleeding and ulceration with corticosteroids, SSRIs, clopidogrel and ticlopidine. Increased risk of haematotoxicity with zidovudine.
Action
Description: Lonazolac inhibits prostaglandin synthesis by decreasing the activity of the cyclooxygenase enzyme.
Disclaimer: This information is independently developed by MIMS based on Lonazolac from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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