Hypersensitivity to nomegestrol acetate or to any of the excipients of Lutenyl.
Active or past history of arterial thromboembolism (in particular, myocardial infarction, cerebrovascular stroke), and venous thromboembolism (in particular, phlebitis, pulmonary embolism).
Serious disturbances of liver function.
Undiagnosed genital bleeding.
Use in pregnancy: Lutenyl is not indicated during pregnancy. The results of a number of epidemiological studies have ruled out the risk of malformation (urogenital or other) resulting from the administration of progestins in early pregnancy. The risks associated with sexual differentiation of the foetus (particularly female), which have been described with older, highly androgenmimetic progestins, have not been extrapolated to recent progestins, which are not or are much less, androgen-mimetic (including the progestin used in Lutenyl).