Aluminum and magnesium containing antacids reduce the peak serum levels (rate) but not the AUC (extent) of Azithromycin absorption. However, each dose should be taken at least 1 hour before or 2 hours after antacids administration.
Azithromycin did not alter the anticoagulant effect of a single 15 mg dose of warfarin. Therefore Azithromycin and warfarin may be co-administered, but prothrombin time should be monitored.
Because of the theoretical possibility of ergotism, Azithromycin and ergot derivatives should not be co-administered.
Some of the related macrolide antibiotics interfere with the metabolisms of cyclosporine.
Concomitant administration of Azithromycin and Digoxin may elevate Digoxin levels.
Administration of Cimetidine 2 hours before Azithromycin had no effect on the absorption of Azithromycin.
Azithromycin may increase serum concentrations of Theophylline or Carbamazepine.