Loratadine: A clinical interaction study was conducted with loratadine. No interactions were observed.
Inhibitors of cytochrome P450 3A4: Mometasone furoate is primarily and extensively metabolized in the liver to multiple metabolites. In vitro studies have confirmed the primary role of cytochrome CYP 3A4 in the metabolism of this compound. Co-administration with ketoconazole, a potent CYP 3A4 inhibitor, may increase the plasma concentrations of mometasone furoate.