Pharmacotherapeutic group: decongestants and other nasal preparations for topical use-corticosteroids.
Pharmacology: Mometasone furoate is a topical glucocorticosteroid with local anti-inflammatory properties at doses that are not systemically active.
It is likely that much of the mechanism for the antiallergic and anti-inflammatory effects of mometasone furoate lies in its ability to inhibit the release of mediators of allergic reactions. Mometasone furoate significantly inhibits the release of leukotrienes from leucocytes of allergic patients.
Mometasone furoate demonstrated potency in inhibition of synthesis and release of IL-1, IL-5, IL-6 and TNFα. It is also a potent inhibitor of leukotriene production. In addition, it is an inhibitor of the production of the Th 2 cytokines, IL-4 and IL-5, from human CD4+ T-cells.