Natexam

Natexam

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Concise Prescribing Info
Contents
Per 1.5/5 mg MR tab Indapamide 1.5 mg, amlodipine 5 mg. Per 1.5/10 mg MR tab Indapamide 1.5 mg, amlodipine 10 mg
Indications/Uses
Substitution therapy for treatment of essential HTN in patients already controlled w/ indapamide & amlodipine given concurrently at the same dose level.
Dosage/Direction for Use
1 tab once daily preferably in the morning.
Administration
May be taken with or without food: Swallow whole w/ water, do not chew.
Contraindications
Hypersensitivity. Haemodynamically unstable heart failure after acute MI, severe hypotension, shock, hypokalaemia, obstruction of the outflow tract of the left ventricle (eg, high grade aortic stenosis). Severe renal failure, hepatic encephalopathy or severe liver function impairment. Lactation.
Special Precautions
Hypertensive crisis, blood glucose, cardiac failure, renal function, uric acid.
Adverse Reactions
Somnolence, dizziness, headache, palpitations, flushing, abdominal pain, nausea, ankle swelling, oedema & fatigue.
Drug Interactions
Combination requiring precautions for use: Torsades de pointes-inducing medicines, NSAIDs, ACE inhibitors. Combination to be taken into consideration: K-sparing diuretics (eg, amiloride, spironolactone, triamterene), metformin, iodinated contrast media, imipramine-like antidepressants, neuroleptics, Ca (salts), ciclosporin, tacrolimus, corticosteroids, tetracosactide.
ATC Classification
C08GA02 - amlodipine and diuretics ; Belongs to the class of calcium-channel blockers in combination with diuretics. Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Natexam 1.5/10 mg MR tab
Packing/Price
1's (Rp265,900/pak)
Form
Natexam 1.5/5 mg MR tab
Packing/Price
1's
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