Nesp

Nesp

darbepoetin alfa

Manufacturer:

Dexa Medica
Concise Prescribing Info
Contents
Darbepoetin α
Indications/Uses
Anemia associated w/ chronic kidney disease in patients on hemodialysis or not on dialysis.
Dosage/Direction for Use
Hemodialysis patient Initial dose: 20 mcg as single IV inj once wkly. Switching from erythropoietin prep: 15-60 mcg as single IV inj once wkly. Maintenance dose: 15-60 mcg as single IV inj once wkly. If alleviation of anemia is maintained, change dose to 30-120 mcg as single IV once every 2 wk. Patient w/ chronic kidney disease not on dialysis Initial dose: 30 mcg as single IV/SC inj once every 2 wk. Switching from erythropoietin prep 30-120 mcg as single IV/SC inj once every 2 wk. Maintenance dose: 30-120 mcg as single IV/SC inj once every 2 wk. If alleviation of anemia is maintained once every 2 wk inj, change to 60-180 mcg as single IV/SC inj once every 4 wk.
Contraindications
Patient w/ history of hypersensitivity to darbepoetin α or other erythropoietin prep. Uncontrolled HTN.
Special Precautions
Patients w/ or who have history of MI, pulmonary, cerebral infarction who may experience thromboembolism. Monitor patients w/ HTN. Patients w/ history of hypersensitivity to any drug, allergic predisposition, cancer, chronic kidney disease. Confirm diagnosis of renal anemia prior to use. Not be used in patients w/ other types of anemia eg, hemorrhagic anemia, pancytopenia. May increase BP & induce hypertensive encephalopathy. Carefully assess the risk of reaction eg, shock. Monitor at regular intervals Hb conc & hematocrit level until the target range is reached & levels are stable. Discontinue use if pure red cell aplasia is diagnosed. Hyperkalemia. Appropriate dietary control is required. Fe should be administered to patients w/ Fe deficiency. Carefully monitor the blood flow through shunts & hemodialyzers; serum creatinine conc & CrCl. Closely monitor body fluid & electrolyte balance, renal function & BP in patients w/ chronic kidney disease not on dialysis. Not recommended in pregnant women or women who may possibly be pregnant. Lactating women.
Adverse Reactions
Increased BP. Increased eosinophils; headache, malaise; shunt thrombosis/occlusion, increased LDH.
Drug Interactions
Potential interaction w/ substances highly bound to RBC eg, cyclosporine & tacrolimus.
ATC Classification
B03XA02 - darbepoetin alfa ; Belongs to the class of other antianemic preparations. Used in the treatment of anemia.
Presentation/Packing
Form
Nesp soln for inj 40 mcg/0.5 mL
Packing/Price
1's
Form
Nesp soln for inj 30 mcg/0.5 mL
Packing/Price
1's
Form
Nesp soln for inj 120 mcg/0.5 mL
Packing/Price
1's
Form
Nesp soln for inj 60 mcg/0.5 mL
Packing/Price
1's
Form
Nesp soln for inj 20 mcg/0.5 mL
Packing/Price
1's
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