Patients w/ or who have history of MI, pulmonary, cerebral infarction who may experience thromboembolism. Monitor patients w/ HTN. Patients w/ history of hypersensitivity to any drug, allergic predisposition, cancer, chronic kidney disease. Confirm diagnosis of renal anemia prior to use. Not be used in patients w/ other types of anemia eg, hemorrhagic anemia, pancytopenia. May increase BP & induce hypertensive encephalopathy. Carefully assess the risk of reaction eg, shock. Monitor at regular intervals Hb conc & hematocrit level until the target range is reached & levels are stable. Discontinue use if pure red cell aplasia is diagnosed. Hyperkalemia. Appropriate dietary control is required. Fe should be administered to patients w/ Fe deficiency. Carefully monitor the blood flow through shunts & hemodialyzers; serum creatinine conc & CrCl. Closely monitor body fluid & electrolyte balance, renal function & BP in patients w/ chronic kidney disease not on dialysis. Not recommended in pregnant women or women who may possibly be pregnant. Lactating women.