Haemophilia A or B w/ inhibitors or expected to have a high anamnestic response
Administer initial dose of 90 mcg/kg by IV bolus inj at 2-3 hr dose interval, further inj may be given if required until haemostasis is obtained. Mild to moderate bleeding episodes
2-3 inj of 90 mcg/kg at 3 hr dose interval & 1 additional dose of 90 mcg/kg if required; or 1 inj of 270 mcg/kg. Serious bleeding episodes
Initially 90 mcg/kg. The following dose varies according to the type & severity of the haemorrhage. Dosing frequency should initially be every 2nd hr until clinical improvement is observed. If continued therapy is indicated, the dose interval can then be increased to 3 hr for 1-2 days. Interval may be increased to every 4, 6, 8 or 12 hr as per indication in 2-3 wk treatment period. Invasive procedure/surgery
Initially 90 mcg/kg before intervention, repeat after 2 hr, then administer at 2-3 hr dose interval for the 1st 24-48 hr. In major surgery, continue treatment at 2-4 hr interval for 6-7 days, may be increased to 6-8 hr interval for another 2 wk in a 2-3 wk treatment period until healing has occurred. Acquired haemophilia
Administer initial dose of 90 mcg/kg by IV bolus inj at 2-3 hr dose interval, further inj may be given if required. Once haemostasis is achieved, interval may be increased to every 4, 6, 8 or 12 hr as long as treatment is indicated. Factor VII deficiency
15-30 mcg/kg at 4-6 hr interval until haemostasis is obtained. Glanzmann's thromboasthenia
90 mcg (range: 80-120 mcg)/kg at 2 hr (1.5-2.5 hr) interval. At least 3 doses should be given to secure effective haemostasis. Administer slowly via IV bolus inj over 2-5 min.