Ornidazole


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Amoebiasis 0.5 g twice daily for 5-10 days. Amoebic dysentery 1.5 g once daily for 3 days. Giardiasis 1-1.5 g once daily for 1-2 days. Trichomoniasis 1.5 g once daily for 5 days. Treat sexual partners concomitantly. IV Severe amoebic dysentery; Amoebic liver abscess Initial: 0.5-1 g, then 0.5 g 12 hrly for 3-6 days. Anaerobic bacterial infections Initial: 0.5-1 g, then 1 g/day in 1-2 divided doses for 5-10 days. Substitute w/ 500 mg 12 hrly PO as soon as possible. Surgical prophylaxis 1 g 30 mins pre-op.
Dosage Details
Intravenous
Prophylaxis of postoperative anaerobic bacterial infections
Adult: 1 g by IV about 30 minutes before surgery.

Intravenous
Anaerobic bacterial infections
Adult: Initially, 0.5-1 g followed by 1 g daily as a single dose or in 2 divided doses for 5-10 days. Doses to be given via infusion. Substitute with 500 mg every 12 hr orally as soon as possible.
Child: 10 mg/kg every 12 hr for 5-10 days.

Intravenous
Severe amoebic dysentery, Amoebic liver abscess
Adult: Initially, 0.5-1 g infusion followed by 0.5 g every 12 hrs for 3-6 days.
Child: 20-30 mg/kg body wt daily.

Oral
Amoebic dysentery
Adult: 1.5 g as a single daily dose for 3 days. Alternatively for patients >60 kg: 1 g bid for 3 days.
Child: 40 mg/kg daily.

Oral
Trichomoniasis
Adult: 1.5 g as a single daily dose or 0.5 g bid for 5 days. Treat sexual partners concomitantly.
Child: 25 mg/kg as a single dose.

Oral
Amoebiasis
Adult: 0.5 g bid for 5-10 days.
Child: 25 mg/kg as a single daily dose for 5-10 days.

Oral
Giardiasis
Adult: 1-1.5 g as a single daily dose for 1-2 days.
Child: 30-40 mg/kg daily.
Renal Impairment
Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.
Hepatic Impairment
Severe: Double the interval between doses.
Administration
Should be taken with food.
Reconstitution
Intravenous:
Dilute to a concentration of ≤5 mg/ml.
Contraindications
Hypersensitivity to ornidazole or to other nitroimidazole derivatives.
Special Precautions
Renal and hepatic impairment. CNS diseases e.g. epilepsy or multiple sclerosis. May impair ability to drive or operate machinery. Pregnancy and lactation.
Adverse Reactions
Somnolence, headache, nausea, vomiting, dizziness, tremor, rigidity, poor coordination, seizures, tiredness, vertigo, temporary loss of consciousness and signs of sensory or mixed peripheral neuropathy, taste disturbances, abnormal LFTs, skin reactions.
Drug Interactions
Potentiates effect of coumarin-type oral anticoagulants. Prolongs the muscle-relaxant effect of vecuronium bromide.
Action
Description: Ornidazole is a 5-nitroimidazole derivative active against protozoa and anaerobic bacteria. It is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms.
Pharmacokinetics:
Absorption: Readily absorbed (oral and intravaginal); peak plasma concentrations after 2 hr (oral), 12 hr (intravaginal).
Distribution: Body tissues and fluids (wide), CSF. Protein-binding: <15%.
Metabolism: Hepatic.
Excretion: Via urine (as conjugates and metabolites), via faeces (small amounts); 12-14 hr (elimination half-life).
Disclaimer: This information is independently developed by MIMS based on Ornidazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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