Oral Adjunct in weight gain, Bone pain associated with osteoporosis, Offset protein catabolism with prolonged corticosteroid administration
Adult: 2.5-20 mg daily in 2-4 divided doses. Usual course: 2-4 wk, may be repeated intermittently as required. Child: ≤0.1 mg/kg daily, in 2-4 divided doses. Usual course: 2-4 wk, may be repeated intermittently as required. Elderly: 5 mg bid for 2-4 wk.
Known or suspected prostate cancer; breast cancer, nephrosis, hypercalcaemia. Pregnancy.
Monitor LFT, lipid profile, Hb, haematocrit; urine and serum Ca levels in women w/ metastatic breast cancer. Assess bone maturation in childn via radiographic examination. Monitor signs of virilisation in women.
Increased risk of bleeding w/ oral anticoagulants (e.g. warfarin). May increase the effects of oral hypoglycaemic agents. Increased risk of oedema w/ corticosteroids and ACTH.
May decrease T4 level, protein-bound iodine, and radioactive iodine uptake.
Description: Oxandrolone is a synthetic testosterone derivative w/ androgenic and anabolic properties which causes increase in lean body mass, body cell mass, muscle strength as well as bone mineral content and density. It also increases protein anabolism and amino acid utilisation and enhances production of erythrocytes. It may also supress spermatogenesis at high doses. Pharmacokinetics: Absorption: Rapidly absorbed from the GI tract. Time to peak plasma concentration: Approx 1 hr. Distribution: Plasma protein binding: 95%. Excretion: Mainly via urine (28%, as unchanged drug); faeces (small amount). Elimination half-life: 9-13 hr.
A14AA08 - oxandrolone ; Belongs to the class of androstan derivative anabolic steroids used as systemic anabolic agents.
Anon. Oxandrolone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 29/08/2017.Buckingham R (ed). Oxandrolone. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 29/08/2017.McEvoy GK, Snow EK, Miller J et al (eds). Oxandrolone. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 29/08/2017.Oxandrolone Tablets, USP (Par Pharmaceutical). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 29/08/2017.Oxandrolone Tablets, USP CIII (Upsher-Smith Laboratories, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 29/08/2017.