Panitumumab

Intravenous
Metastatic colorectal cancer

Dilute vial labelled as containing 20 mg/mL with NaCl 0.9% to a total volume of 100 mL for dosage <1,000 mg and 150 mL for dosage >1,000 mg, to provide a concentration not exceeding 10 mg/mL. Do not shake. Gently invert to mix.

Interstitial pneumonitis or pulmonary fibrosis, RAS mutation-positive metastatic colorectal cancer or unknown RAS mutation status. Lactation. Concomitant use of bevacizumab-containing and IFL (irinotecan, 5-fluorouracil and leucovorin)-containing chemotherapy.

Patient with history of keratitis, ulcerative keratitis or severe dry eye. Pregnancy.

Significant: Infusion reactions (e.g. fever, chills, hypotension), photosensitivity, dermatologic toxicities (e.g. erythema, pruritus, rash, dry skin, skin fissures, skin exfoliation, acneiform dermatitis, paronychia, local abscesses), electrolyte depletion (e.g. hypomagnesemia, hypokalaemia , keratitis or ulcerative keratitis.
Blood and lymphatic system disorders: Anaemia, leucopenia.
Cardiac disorders: Tachycardia.
Eye disorders: Abnormal eyelashes growth, blepharitis, dry eye, eye pruritus or irritation, conjunctivitis.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, constipation, dyspepsia, GERD, abdominal pain, rectal haemorrhage, dry mouth, cheilitis, stomatitis or aphthous ulcer.
General disorders and administration site conditions: Fatigue, weakness, asthenia, pyrexia, chills, mucosal inflammation, peripheral oedema, pain.
Immune system disorders: Hypersensitivity reactions, antibody formation.
Infections and infestations: Folliculitis, cellulitis, localised infection, paronychia.
Investigations: Decreased weight.
Metabolism and nutrition disorders: Decreased appetite, dehydration, hyperglycaemia, hypocalcaemia, hypophosphataemia, hypokalaemia.
Musculoskeletal and connective tissue disorders: Back pain, pain in extremity.
Nervous system disorders: Headache, dizziness.
Psychiatric disorders: Insomnia, anxiety.
Renal and urinary disorders: UTI.
Respiratory, thoracic and mediastinal disorders: Cough, dyspnoea, pulmonary embolism, epistaxis.
Skin and subcutaneous tissue disorders: Alopecia, hypertrichosis, hyperhidrosis, palmar-plantar erythrodysaesthesia syndrome, skin ulcer, nail disorder (e.g. onychoclasis).
Vascular disorders: Flushing, hypertension, deep vein thrombosis.
Potentially Fatal: Severe dermatological toxicities (e.g. necrotising fasciitis, sepsis, Stevens-Johnson syndrome, toxic epidermal necrolysis), severe diarrhoea, dehydration. Rarely, bullous mucocutaneous disease, infusion-related toxicities (e.g. bronchospasm, hypotension, angioedema, anaphylaxis), interstitial lung disease, pulmonary fibrosis.

This drug may cause dizziness and blurred vision, if affected, do not drive or operate machinery. Patients should wear protective clothing and/or use sunscreen when exposed to sunlight during treatment.

Perform RAS genotyping of tumour tissue before initiation of therapy. Monitor serum electrolytes (e.g. Ca, Mg, K) periodically and for at least 8 weeks after discontinuation of treatment. Monitor for infusion-related events, signs and symptoms of dermatological or pulmonary toxicities, keratitis or ulcerative keratitis.

Potentially Fatal: Increased incidence of adverse reactions (e.g. dermatologic toxicities, severe diarrhoea and dehydration) with bevacizumab-containing chemotherapy. Increased incidence of severe diarrhoea with IFL-containing chemotherapy.

Description: Panitumumab is a recombinant, human IgG₂ kappa monoclonal antibody that binds to the epidermal growth factor receptor (EGFR), thereby inhibiting phosphorylation and activation of intracellular tyrosine kinases resulting in inhibition of cell growth, proliferation, transformation and overall survival of tumour cells.
Pharmacokinetics:
Excretion: Elimination half-life: Approx 7.5 days.

Store between 2-8°C. Do not freeze. Protect from light.

Targeted Cancer Therapy

L01XC08 - panitumumab ; Belongs to the class of monoclonal antibodies, other antineoplastic agents. Used in the treatment of cancer.

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Buckingham R (ed). Panitumumab. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/04/2018.

Joint Formulary Committee. Panitumumab. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/04/2018.

Vectibix Solution (Amgen Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 10/04/2018.