Generic Medicine Info
Indications and Dosage
Susceptible infections
Adult: 400 mg bid.

Acute uncomplicated cystitis in women, Gonococcal urethritis in men
Adult: 800 mg as single dose.
Renal Impairment
Dose reduction may be necessary.
Should be taken with food.
Hypersensitivity to quinolones, children <12 yr, pregnancy, lactation.
Special Precautions
Underlying CNS disease; hepatic disease; renal impairment. Avoid sun exposure, may cause severe sunburn.
Adverse Reactions
Nausea, vomiting, gastric pain, dizziness, insomnia, allergic skin reactions, thrombocytopaenia, leukopenia/neutropenia, photosensitisation, arthropathy, muscular pain, headache, delusions, depression, hallucinations, hepatic dysfunction.
Drug Interactions
Reduced absorption with antacids, didanosine (DDI), iron salts, pirenzepine, sucralfate, vincristine, zinc salts; increased levels with cimetidine, probenecid, theophylline; increases the levels of cyclosporine; causes seizures with foscarnet, NSAIDs, piroxicam; hypoglycemia with glimeperide; antagonistic with quercetin.
Description: Pefloxacin is a fluoroquinolone antibacterial that exhibits its bactericidal action by inhibition of DNA gyrase and topoisomerase IV which are needed for bacterial DNA reproduction.
Metabolism: Extensive metabolism; converted to N-desmethylpefloxacin (norfloxacin).
Excretion: 8-13 hr (elimination half-life).
Store at room temperature. Keep away from excess heat and moisture.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Pefloxacin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by
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