As an adjunct to diet & exercise to improve glycemic control in adult w/ type 2 DM not adequately controlled on metformin HCl or pioglitazone alone, or treated already w/ the combination of pioglitazone & metformin HCl, as separate tab.
Dosage/Direction for Use
Patient inadequately controlled on Metformin monotherapy 15 mg/500 mg or 15 mg/850 mg once or twice daily. Patient who initially responded to pioglitazone monotherapy & require additional glycemic control 15 mg/500 mg twice daily or 15 mg/850 mg once daily. Patient switching from combination therapy of pioglitazone plus metformin as separate tab 15 mg/500 mg or 15 mg/850 mg based on the dose of pioglitazone or metformin already being taken.
Administration
Should be taken with food.
Contraindications
Cardiac failure or history of cardiac failure (NYHA stages I-IV); acute or chronic disease which may cause tissue hypoxia eg, cardiac or resp failure, recent MI, shock, hepatic impairment, acute alcohol intoxication, renal failure or dysfunction (CrCl <60 mL/min). Pregnancy & lactation.
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