Piribedil

Oral
Circulatory disorders

Oral
Monotherapy in Parkinson's disease

Should be taken with food. Take at the end of a main meal.

Hypersensitivity, CV collapse, acute myocardial infarction, uncontrolled hypertension, pregnancy.

Raynaud's syndrome, history of psychosis, renal impairment. May cause hypotension in the first few days of treatment. Regular ophthalmological monitoring is recommended. Lactation.

Nausea, vomiting, dizziness, confusion, drowsiness, hypothermia, dyskinesias, occasional changes in liver function. Raynaud's syndrome or digital vasospasm, leg cramps.

Clonidine and dopamine antagonists eg, phenothiazines and haloperidol may antagonise effects of piribedil.

Description: Piribedil is a non-ergot dopamine D₂ agonist that stimulates cerebral and peripheral dopamine receptors and corrects dopamine deficiency. It is used largely, as an adjunct to levodopa therapy in the treatment of Parkinson's disease.

Antiparkinsonian Drugs / Peripheral Vasodilators & Cerebral Activators