Precedex

Precedex Dosage/Direction for Use

dexmedetomidine

Manufacturer:

Pfizer
Full Prescribing Info
Dosage/Direction for Use
Adult: Precedex should be individualized and titrated to the desired clinical effect. It is recommended to initiate Precedex with a loading dose of 1 mcg/kg over 10 mins, followed by a maintenance infusion in the range of 0.2-0.7 mcg/kg/hr. Maintenance infusion rate can be adjusted in order to achieve the desired clinical effect. Dosages as low as 0.05 mcg/kg/hr have been used in clinical studies. In clinical trials, infusions up to 24 hrs have been studied.
Precedex has been administered to patients requiring mechanical ventilation as well as to patients breathing spontaneously after extubation. There is no respiratory depression associated with Precedex administration.
Impaired Hepatic Function: Dosage reductions may need to be considered for patients with hepatic impairment, as dexmedetomidine hydrochloride is metabolized primarily in the liver.
Impaired Renal Function: No dosage adjustment is necessary.
Elderly: No dosage adjustment is necessary in elderly patients.
Children: Safety and efficacy of Precedex have not been studied in children.
Administration: A controlled infusion device should be used to administer Precedex.
Strict aseptic technique must always be maintained during handling of Precedex infusion. Preparation of infusion solutions is the same, whether for the loading or maintainance dose. To prepare the infusion, withdraw 2 mL of Precedex concentration for solution for infusion and add to 48 mL of sodium chloride 0.9% to total 50 mL. Shake gently to mix well. A controlled infusion device should be used to administer Precedex. After dilution, Precedex is intended for immediate use and should be discarded after 24 hrs.
Parenteral products should be inspected visually for particulate matter and discoloration prior to administration.
Ampoules are intended for single-patient use only.
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