Pregex

Pregex

pregabalin

Manufacturer:

Amarox
Concise Prescribing Info
Contents
Pregabalin
Indications/Uses
Peripheral & central neuropathic pain in adults. As adjunctive therapy in adults w/ partial seizures w/ or w/o secondary generalization. Generalized anxiety disorder in adults. Reduce pain in the management of fibromyalgia.
Dosage/Direction for Use
150-600 mg/day in 2 or 3 divided doses. Neuropathic pain Initially 75 mg twice daily. May be increased to 150 mg twice daily after 3-7 day interval. Max: 300 mg twice daily after an additional wk. Epilepsy Initially 75 mg twice daily. May be increased to 150 mg twice daily after 1 wk. Max: 300 mg twice daily after an additional wk. Generalized anxiety disorder 150-600 mg/day in 2-3 divided doses. Treatment can be started w/ 150 mg/day. May be increased to 300 mg/day after 1 wk. Following an additional wk, dose may be increased to 450 mg/day. Max dose: 600 mg/day may be achieved after an additional wk. Fibromyalgia Recommended dose: 300-450 mg/day in 2 divided doses. Initially 75 mg twice daily (150 mg/day), may be increased to 150 mg twice daily (300 mg/day) w/in 1 wk. Patients who do not experience sufficient benefit w/ 300 mg/day may be further increased to 225 mg twice daily (450 mg/day). Renal impairment CrCl ≥60 mL/min Initially 150 mg twice daily. Max dose: 600 mg/day, CrCl 30-60 mL/min Initially 75 mg once or twice daily. Max dose: 300 mg/day, CrCl 15-30 mL/min Initially 25-50 mg once or twice daily. Max dose: 150 mg/day, CrCl <15 mL/min Initially 25 mg once daily. Max dose: 75 mg/day. Supplementary dose following haemodialysis Initially 25 mg/day single dose. Max: 100 mg/day.
Administration
May be taken with or without food.
Contraindications
Special Precautions
Patients w/ rare hereditary problems of galactose intolerance, Lapp-lactase deficiency or glucose-galactose malabsorption. Adjust hypoglycemic medications in some diabetic patients who gain wt on pregabalin treatment. Discontinue immediately if symptoms of angioedema eg, facial, perioral, or upper airway swelling occur. Associated w/ dizziness & somnolence that may increase accidental injury/fall in elderly. Loss of consciousness, confusion & mental impairment. Transient visual blurring & other changes in visual acuity. W/drawal symptoms. Evaluate patients for history of drug misuse & abuse & observe for signs of pregabalin abuse. CHF patients. Increased CNS adverse events especially somnolence in the treatment of central neuropathic pain due to spinal cord injury. May influence ability to drive or use machines due to dizziness & somnolence. Do not drive, operate complex machinery or engage in other potentially hazardous activities. Renal impairment. Effective contraception must be used in women of childbearing potential. Pregnancy & lactation. Childn. Elderly.
Adverse Reactions
Dizziness, somnolence; headache. Nasopharyngitis; appetite increased; euphoric mood, confusion, libido decreased, irritability, depression, disorientation, insomnia; ataxia, disturbance in attention, coordination abnormal, tremor, dysarthria, amnesia, memory impairment, paraesthesia, hypoesthesia, sedation, balance disorder, lethargy; blurred vision, diplopia; vertigo; dry mouth, constipation, flatulence, vomiting, abdominal distention; nausea, diarrhea; muscle cramp, arthralgia, back pain, pain in limb, cervical spasm; fatigue, peripheral oedema, fall, feeling drunk, oedema, abnormal gait; increased wt.
Drug Interactions
May potentiate effects of ethanol & lorazepam. Resp failure & coma in patients who have taken pregabalin w/ other CNS depressant medications. Additive impairment of cognitive & gross motor function caused by oxycodone w/ pregabalin. Reduced lower GI tract function eg, intestinal obstruction, paralytic ileus, constipation w/ opioid analgesics.
ATC Classification
N03AX16 - pregabalin ; Belongs to the class of other antiepileptics.
Presentation/Packing
Form
Pregex cap 150 mg
Packing/Price
1 × 14's
Form
Pregex cap 50 mg
Packing/Price
1 × 14's
Form
Pregex cap 75 mg
Packing/Price
1 × 14's
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