Caution should be exercised in patients known to be hypersensitive to gonadotropin pituitary eg, patients with polycystic syndromes.
Patients should always be monitored for signs of ovarian hyperstimulation (eg, pelvic pain) during administration of clomiphene.
If ovary enlargement or cyst formation has occurred, therapy should be discontinued until the size of the ovary returns to normal; then doses or duration of continuing therapy should be reduced.
If sight disturbances have occurred during clomiphene therapy, treatment should be discontinued and complete ophthalmologic examination should be performed.
Effects on the Ability to Drive or Operate Machinery: Caution should be taken if the job of the patients need a high degree of alertness or high level of mental and physical conditions (eg, machinery operator, driver), especially if working under various lighting since clomiphene citrate may cause sight disturbances, dizziness or lightheadedness.