Risperdal/Risperdal Consta

Risperdal/Risperdal Consta

risperidone

Manufacturer:

Johnson & Johnson
Concise Prescribing Info
Contents
Risperidone
Indications/Uses
Risperdal Acute & chronic schizophrenic psychoses, including 1st episode psychoses, & other psychotic conditions in which positive &/or negative symptoms are prominent. Alleviates affective symptoms associated w/ schizophrenia. Behavioural disturbances in patients w/ dementia. Manic episodes associated w/ bipolar disorders. Conduct & other disruptive behaviour disorders in patients w/ subaverage intellectual functioning or mental retardation. Improves adaptive skills in childn w/ autistic disorder. Risperdal Consta Schizophrenia & schizoaffective disorder. Monotherapy & adjunctive treatment of bipolar I disorder to delay occurrence of mood episodes.
Dosage/Direction for Use
Risperdal Schizophrenia Adult May be given once or twice daily. Initially 2 mg daily. May be increased to 4 mg on the 2nd day. Dosage can be maintained unchanged or further individualized. Max: 16 mg daily. Elderly Initially 0.5 mg twice daily. May be increased to 1-2 mg twice daily. Behavioural disturbances in patients w/ dementia Initially 0.25 mg twice daily. May be adjusted by increments of 0.25 mg twice daily not more frequently than every other day. Optimum dose: 0.5 mg twice daily. Max: 1 mg twice daily. Bipolar mania Adult Initially 2 or 3 mg once daily. Dosage may be adjusted by 1 mg daily increments at intervals not <24 hr. Conduct & other disruptive behaviour disorders Patient ≥50 kg Initially 0.5 mg once daily. May be adjusted by 0.5 mg once daily increments not more frequently than every other day. Optimum dose: 1 mg once daily. Patient <50 kg Initially 0.25 mg once daily. May be adjusted by 0.25 mg once daily increments not more frequently than every other day. Optimum dose: 0.5 mg once daily. Autism Patient <20 kg Initially 0.25 mg daily. May be increased by 0.25 mg on day 4. May increase dose by 0.25 mg at ≥2 wk intervals if response is insufficient. Max: 1.5 mg daily. Patient ≥20 kg Initially 0.5 mg daily. May be increased by 0.5 mg on day 4. May increase dose by 0.5 mg at ≥2 wk intervals if response is insufficient. Max: 2.5 mg daily. Patient >45 kg Max: 3.5 mg daily. Risperdal Consta Adult 25 mg IM every 2 wk. Some patient may benefit from higher doses of 37.5 or 50 mg. Max: 50 mg every 2 wk. Sufficient antipsychotic coverage should be ensured during 3-wk lag period following 1st inj. Upward dose adjustment should not be made more frequently than every 4 wk. Elderly 25 mg IM every 2 wk. Hepatic & renal impairment Initially 0.5 mg twice daily oral risperidone during 1st wk of treatment, then 1 mg twice daily or 2 mg once daily on the 2nd wk. If 2 mg oral dose is well tolerated, give 25 mg Risperdal Consta IM every 2 wk.
Administration
May be taken with or without food: Administer directly from the syringe or mix w/ a beverage (eg, water, coffee, orange juice, low-fat milk) prior to administration.
Special Precautions
Intraoperative floppy iris syndrome may increase risk of eye complications during & post-op. Monitor for symptoms of hyperglycemia & DM; wt gain. History of cardiac arrhythmias, seizures, w/ congenital long QT syndrome, concomitant use of drugs known to prolong QT interval. Priapism. Body temp regulation. Antiemetic effect. Lecopenia, neutropenia & agranulocytosis, venous thromboembolism, tardive dyskinesia/extrapyramidal symptoms, neuroleptic malignant syndrome. Parkinson's disease or dementia w/ lewy bodies. Elderly patients w/ dementia. Risperdal Known CV disease, dosage should be gradually titrated as recommended, a dose reduction should be considered when hypotension occurs. Do not drive or operate machinery. Pregnancy. Women receiving Risperdal should not breastfeed. Elderly. Risperdal Consta For risperidone-naive patients, establish tolerability w/ oral risperidone prior to treatment w/ Risperdal Consta.
Adverse Reactions
Infections & infestations; blood & lymphatic system disorders; hypersensitivity; psychiatric disorders; nervous system disorders; eye disorders; ear & labyrinth disorders; cardiac disorders; vascular disorders; resp, thoracic & mediastinal disorders; GI disorders; skin & SC tissue disorders; musculoskeletal & connective tissue disorders; renal & urinary disorders; reproductive system & breast disorders; injury, poisoning & procedural complications; metabolism & nutrition disorders; hepatobiliary disorders; fatigue, asthenia, pyrexia, chest pain, peripheral edema, pain, abnormal gait, edema, feeling abnormal, body temp increase/decrease, chills, discomfort, drug w/drawal syndrome, face oedema, induration, malaise, peripheral coldness, thirst, pitting oedema, sluggishness; wt increase/decrease, increased blood creatinine phosphokinase, increased heart rate, increased blood prolactin.
Drug Interactions
May antagonize the effect of levodopa & other dopamine agonists. Combination w/ other centrally-acting drugs eg, alcohol. Combination w/ psychostimulants eg, methylphenidate can lead to the emergence of extrapyramidal symptoms. Drugs w/ hypotensive effects. Drugs known to prolong the QT interval. Strong CYP2D6 inhibitors may increase risperidone plasma conc. CYP3A4 &/or P-gp inhibitors may elevate plasma conc of risperidone. Decreased plasma conc w/ CYP3A4 &/or P-gp inducer.
MIMS Class
ATC Classification
N05AX08 - risperidone ; Belongs to the class of other antipsychotics.
Presentation/Packing
Form
Risperdal Consta inj 25 mg
Packing/Price
(+ diluent) 1's (Rp950,250/vial)
Form
Risperdal Consta inj 37.5 mg
Packing/Price
(+ diluent) 1's (Rp950,250/vial)
Form
Risperdal oral soln 1 mg/mL
Packing/Price
30 mL x 1's (Rp375,375/botol)
Form
Risperdal Consta inj 50 mg
Packing/Price
(+ diluent) 1's (Rp1,050,000/vial)
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