Saizen Drug Interactions



PT. Merck Tbk
Full Prescribing Info
Drug Interactions
Concomitant treatment with corticosteroids can inhibit the therapeutic effect of Saizen (see Precautions). Moreover, the following substances can influence the efficacy of somatropin: Gonadotropins, estrogens, androgens and anabolic agents.
There are published in vitro data available indicating that somatropin can increase the clearance of substances that are metabolized by the cytochrome P-450 3A4 eg, sexual steroids, corticosteroids, anticonvulsants and cyclosporin. If somatropin is used together with drugs that are metabolized through CYP-450 3A4-dependent liver enzymes, the clinical efficacy of these drugs should be monitored.
Influence on Diagnostic Methods: Treatment with Saizen can lead to increases in the plasma levels of inorganic phosphorus, alkaline phosphatase and IGF-1.
Incompatibilities: No incompatibilities of Saizen with other pharmaceutical preparations are known at present.
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