Salsalate


Generic Medicine Info
Indications and Dosage
Oral
Fever, Osteoarthritis, Pain, Rheumatoid arthritis
Adult: Up to 3 g daily in divided doses.
Administration
Should be taken with food. Take w/ food or milk.
Contraindications
Haemophilia, haemorrhagic disorders, gout, hypersensitivity to aspirin or NSAIDs. Children <12 yr. Pregnancy (3rd trimester) and lactation. Severe renal or hepatic impairment.
Special Precautions
Peptic ulcers; asthma, allergic disorders. Impaired hepatic or renal function. Dehydrated patients; uncontrolled hypertension. May cause acute haemolytic anaemia in patients with G6PD deficiency.
Adverse Reactions
GI symptoms, hypersensitivity reactions, skin eruptions, angioedema, weakness, rhinitis and dyspnoea, hypoprothrombinaemia. Hepatotoxicity, renal impairment, iron-deficiency anaemia, occult bleeding. Local irritation (rectally); Reye's syndrome.
Potentially Fatal: Paroxysmal bronchospasm, thrombocytopenia, leukopenia.
PO: C, Z (NSAIDs caused foetal ductus arteriosus premature closure, foetal renal impairment and persistent pulmonary hypertension. Avoid near term, else use lowest dose for shortest time.)
Drug Interactions
May increase risk of liver damage when used with gold compounds. GI effects may be enhanced with alcohol or concurrent use with corticosteroids. May increase activity of coumarin anticoagulants, sulfonylureas, zafirlukast, methotrexate, phenytoin and valproate. May decrease the activity of probenecid and sulfinpyrazone.
Potentially Fatal: Increased risk of adverse effects when used with other NSAIDs.
Lab Interference
Glucose oxidase urinary glucose tests: False-negative results. Cupric sulfate method: False-positive. Interferes with Gerhardt test, vanillyl mandelic acid (VMA) determination; 5-hydroxy indole acetic acid (5-HIAA), xylose tolerance test and T3 and T4.
Action
Description: Salsalate is a non-acetylated salicylic acid derivative with analgesic, anti-inflammatory and antipyretic actions similar to those of aspirin. It inhibits prostaglandin synthesis, acts on the hypothalamus heat-regulating center to reduce fever, blocks prostaglandin synthetase thus preventing thromboxane A2 formation.
Onset: Therapeutic: 3-4 days (continuous dosing).
Pharmacokinetics:
Absorption: Each molecule of salsalate is hydrolysed in the small intestines to 2 molecules of salicylic acid.
Excretion: About 13% of salsalate is excreted as glucuronide conjugates in the urine.
Disclaimer: This information is independently developed by MIMS based on Salsalate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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