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Citicoline activates the biosynthesis of phospholipid structures in nerve membranes, increases cerebral metabolism, increases the concentration of various neurotransmitters including acetylcholine and dopamine, shows neuroprotective activity in conditions of hypoxia and ischemia, and improves EEG in a state of loss of consciousness.
In addition, Citicoline inhibits the development of apopleptic stroke and neurological symptoms, increases brain stem blood flow and improves central motor function in patients with cerebrovascular disorders.
Citicoline shows improvement in cerebral function by increasing glucose uptake from the brain inhibiting the accumulation of lactic acid in the brain.
In the case of cerebral ischemia, Citicoline works in conjunction with nerve cell membrane fraction and accelerates biosynthesis of lecithin metabolism.
Loss of consciousness due to head injuries or brain surgery. Accelerate rehabilitation in upper extremity in patients with post-apoplectic hemiplegia.
Disturbances of consciousness due to head injuries or brain surgery: Adult: 100-500 mg, once to twice daily by IV infusion or IV/IM injection. The dose can be adjusted to patient's conditions.
Post-apoplectic hemiplegia: 1000 mg once daily by IV 4 weeks consecutively; or 250 mg once daily by IV 4 weeks consecutively, if the signs of improvement shown, the administration may be continued for up to 4 weeks.
Hypersensitivity to Citicoline.
For patients with acute, severe and progressive disturbances of consciousness due to head injury and brain surgery, Citicoline injection should be administered in conjunction with hemostatics and intracranial pressure relieving drugs, while maintaining body temperature at low levels. In patients with consciousness disturbance of acute cerebral infarction, administration of citicoline should be started within 2 weeks after apoplectic stroke.
If shock symptoms occur such as drastic blood pressure reduction, chest pain and dyspnea, the administration of citicoline should be stopped.
Other side effects that are rarely reported include rash, insomnia, headache, dizziness, excitation, convulsions, numbness, nausea, anorexia, liver dysfunction, transient diplopia, warm sensations, transient changes in blood pressure and malaise.
Store in the temperature below 30°C, protected from light.
N06BX06 - citicoline ; Belongs to the class of other psychostimulants and nootropics.
Inj (amp) 250 mg/2 mL x 5's. 500 mg/4 mL x 5's. 1,000 mg/8 mL x 5's.