Pharmacology: Methylprednisolone is a potent anti-inflammatory steroid. It has a greater anti-inflammatory potency and even less tendency to induce sodium and water retention than prednisolone. Methylprednisolone sodium succinate has the same metabolic and anti-inflammatory actions as methylprednisolone. When given parenterally and in equimolar quantities, the 2 compounds are equivalent in biologic activity. The relative potency of Solu-Medrol and hydrocortisone sodium succinate, as indicated by depression of eosinophil count, following IV administration, is at least 4:1. This is in agreement with the relative oral potency of methylprednisolone and hydrocortisone.