Sufenta

Sufenta

sufentanil

Manufacturer:

Dexa Medica
Concise Prescribing Info
Contents
Sufentanil
Indications/Uses
IV: Analgesic adjunct during induction & maintenance of balanced general anesth; anesth in patients undergoing major surgical procedures. Epidural: Post-op management of pain following general surgery, thoracic or orthopedic procedures & caesarean section; analgesic adjunct to epidural bupivacaine during labor & vag deliveries.
Dosage/Direction for Use
Individualized dosage. IV As analgesic adjunct 0.5-5 mcg/kg. Supplemental doses of 10-25 mcg should be individually adjusted. As anesth agent ≥8 mcg/kg. Supplementary doses of 25-50 mcg maintains CV stability during anesth. Epidural Post-op pain management Initially, 30-50 mcg. Additional boluses of 25 mcg may be administered if there is evidence of lightening of analgesia. As analgesic adjunct during labor & vag delivery 10 mcg to epidural bupivacaine. 2 subsequent inj may be given. Max: 30 mcg.
Contraindications
Known intolerance to any of its components or to other opioids. IV use in labor or before clamping of the cord during caesarean section. Severe hemorrhage or shock; septicemia; inj site infection; thrombocytopenia, coagulopathy; presence of anticoagulant therapy or of other concomitant drug therapy or medical conditions which could contraindicate the technique of epidural administration.
Special Precautions
Patients should remain under appropriate surveillance for resp depression. Resuscitation equipment & opioid antagonists should be readily available. Induction of muscle rigidity & non-epileptic myoclonic movements can occur. Bradycardia & cardiac arrest can occur if the patient has received insufficient amount of anticholinergic or when combined w/ non-vagolytic muscle relaxants. Take measures to maintain stable arterial pressure. Avoid use of rapid bolus inj of opioids in patients w/ compromised intracerebral compliance. Patients on chronic opioid therapy or w/ history of opioid abuse; uncontrolled hypothyroidism; pulmonary disease; decreased resp reserve; alcoholism. W/ epidural administration, presence of resp depression or compromised resp function & presence of foetal distress. Impaired hepatic or renal function. Pregnancy & lactation. Elderly & debilitated patients.
Adverse Reactions
Sedation, neonatal tremor, dizziness, headache; tachycardia; HTN, hypotension, pallor; neonatal cyanosis; nausea, vomiting; pruritus, skin discoloration; muscle twitching; urinary retention, urinary incontinence; pyrexia.
Drug Interactions
Barbiturates, benzodiazepines, neuroleptics, general anesth, other non-selective CNS depressants eg, alcohol may potentiate resp depression of opioids. Inhibition of metabolism w/ CYP3A4 inhibitors eg, ketoconazole, itraconazole, ritonavir. Co-administration w/ SSRIs, SNRIs or MAOIs may increase the risk of serotonin syndrome.
MIMS Class
ATC Classification
N01AH03 - sufentanil ; Belongs to the class of opioid anesthetics. Used as general anesthetics.
Presentation/Packing
Form
Sufenta inj 5 mcg/mL
Packing/Price
10 mL x 5 × 1's (Rp1,240,000/boks)
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