Salbutamol solution for inhalation may cause a fine tremor of skeletal muscle in some patients, usually the hands are most obviously affected. This effect is common to all β-adrenergic stimulants.
In patient who are unusually sensitive to β-adrenergic stimulants, peripheral vasodilatation and a compensatory small increase in heart rate may occur.
There have been very rare reports of transient muscle cramps.
Hypersensitivity reactions including angioedema, urticaria, bronchospasm, hypotension and collapse have been reported very rarely. As with other inhalation therapy, the potential for paradoxical bronchospasm should be kept in mind. If it occurs, the preparation should be discontinued immediately and alternative therapy instituted.
As with other inhalation therapy, the potential for paradoxical bronchospasm may occur with an immediate increase in sneezing after dosing. This should be treated immediately with an alternative presentation or a different fast-acting inhaled bronchodilator. Salbutamol solution for inhalation should be discontinued immediately, the patient assessed, and if necessary alternative therapy instituted.
Potentially serious hypokalemia may result from β2 agonist therapy.
As with other β2 agonist hyperactivity has been reported rarely in children.
Mouth and throat irritation may occur with inhaled salbutamol.