The recommended oral dosage of Tarivid is as follows (before or after meals): Urinary Tract Infections: 200-400 mg daily in 1-2 divided doses for 1-10 days. Severe or Complicated Infections: Up to 600 mg daily and/or for up to 20 days.
Lower Respiratory Tract Infections: 200-600 mg daily in 1-3 divided doses for 3-10 days. Severe or Complicated Infections: Up to 800 mg daily and/or for up to 20 days.
Skin and Soft Tissue Infections: 400 mg daily for 7 days.
Gynaecological Infections: 400 mg daily for 7 days.
Uncomplicated Gonococcal Urethritis: A single dose of 200-400 mg.
Nongonococcal Urethritis: 400 mg daily for 9 days.
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Patients with Impaired Renal Function: Dosage should be adjusted for patients with a creatinine clearance ≤50 mL/min. After a normal initial dose, dosage should be adjusted as follows: Creatinine clearance 20-50 mL/min: Maintenance dose is the usual recommended dose every 24 hrs; creatinine clearance <20 mL/min: Administer ½ the usual recommended unit dose every 24 hrs.
Patients with Cirrhosis: The excretion of ofloxacin may be reduced in patients with severe liver function disorders (eg, cirrhosis with or without ascites). A maximum dose of 400 mg of ofloxacin/day should therefore not be exceeded.
When the patient's condition has improved, it is possible to switch from IV administration to oral medication in the same dosage. Until further experience has been obtained, the duration of treatment should not exceed 2 months.