Adult & childn ≥12 yr 12 g piperacillin/1.5 g tazobactam given in divided doses every 6 or 8 hr.
Severe infections 18 g piperacillin/2.25 g tazobactam in divided doses daily.
Neutropenia Adult & Childn ≥12 yr 4 g piperacillin/500 mg tazobactam
Childn >50 kg Adult dose in combination w/ aminoglycoside,
<50 kg 80 mg piperacillin/10 mg tazobactam/kg every 6 hr in combination w/ aminoglycoside.
Renal impairment CrCl 20-80 mL/min 12 g piperacillin/1.5 g tazobactam/day in divided doses of 4 g/500 mg every 8 hr;
CrCl <20 mL/min 8 g piperacillin/1 g tazobactam/day in divided doses of 4 g/500 mg every 12 hr. Max: 2.25 g every 8 hr. All doses to be given by slow IV infusion (eg, over 20-30 min) or inj (over at least 3-5 min).
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