Tazocin

Tazocin

piperacillin + tazobactam

Manufacturer:

Pfizer
Concise Prescribing Info
Contents
Per 4.5 g Piperacillin 4 g, tazobactam 500 mg
Indications/Uses
Moderate to severe infections caused by piperacillin-resistant, piperacillin/tazobactam susceptible, β-lactamase producing strains in the following conditions: Appendicitis (complicated by rupture or abscess) & peritonitis. Uncomplicated & complicated skin & skin structure infections. Postpartum endometritis or pelvic inflammatory disease. Moderate community-acquired pneumonia. In combination w/ aminoglycoside is recommended in febrile neutropenic infection in adult & childn.
Dosage/Direction for Use
Adult & childn ≥12 yr 12 g piperacillin/1.5 g tazobactam given in divided doses every 6 or 8 hr. Severe infections 18 g piperacillin/2.25 g tazobactam in divided doses daily. Neutropenia Adult & Childn ≥12 yr 4 g piperacillin/500 mg tazobactam Childn >50 kg Adult dose in combination w/ aminoglycoside, <50 kg 80 mg piperacillin/10 mg tazobactam/kg every 6 hr in combination w/ aminoglycoside. Renal impairment CrCl 20-80 mL/min 12 g piperacillin/1.5 g tazobactam/day in divided doses of 4 g/500 mg every 8 hr; CrCl <20 mL/min 8 g piperacillin/1 g tazobactam/day in divided doses of 4 g/500 mg every 12 hr. Max: 2.25 g every 8 hr. All doses to be given by slow IV infusion (eg, over 20-30 min) or inj (over at least 3-5 min).
Contraindications
Hypersensitivity to any β-lactams (including penicillins, cephalosporins) or β-lactamase inhibitors.
Special Precautions
Bleeding, hematopoietic function, renal impairment. Pregnancy & lactation.
Adverse Reactions
Diarrhea, constipation, nausea, headache, insomnia, rash, erythema, pruritus, vomiting, hypersensitivity reactions, urticaria & superinfection.
Drug Interactions
Vecuronium, heparin, oral anticoagulants, other drugs affecting blood coagulation system. Methotrexate, probenecid, tobramycin.
MIMS Class
Penicillins
ATC Classification
J01CR05 - piperacillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Presentation/Packing
Form
Tazocin powd for inj
Packing/Price
(vial) 4.5 g x 12 × 1's (Rp4,986,790/boks)
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