Adverse reactions listed in CIOMS frequency categories include: Very common: ≥10%, common: ≥1%, uncommon: ≥0.1% and <1%, rare: ≥0.01% and <0.1%, very rare: <0.01%.
Infections and Infestations:
Uncommon: Candidal superinfection.
Blood and Lymphatic System:
Uncommon: Leukopenia, neutropenia, thrombocytopenia. Rare: Anemia, bleeding manifestations (including purpura, epistaxis, prolonged bleeding time), eosinophilia, haemolytic anemia. Very Rare: Agranulocytosis, positive direct Coombs' test, pancytopenia, prolonged partial thromboplastin time, prolonged prothrombin time, thrombocytosis.
Immune System Disorders:
Uncommon: Hypersensitivity reaction. Rare: Anaphylactic/anaphylactoid reaction (including shock).
Metabolism and Nutrition Disorders:
Very Rare: Decreased blood albumin, decreased blood glucose, decreased blood total protein, hypokalemia.
Nervous System Disorders:
Uncommon: Headache, insomnia.
Uncommon: Hypotension, phlebitis, thrombophlebitis. Rare: Flushing.
Common: Diarrhea, nausea, vomiting. Uncommon: Constipation, dyspepsia, jaundice, stomatitis. Rare: Abdominal pain, pseudomembranous colitis.
Uncommon: Increased alanine aminotransferase, increased aspartate aminotransferase. Rare: Increased bilirubin, increased blood alkaline phosphatase, increased γ-glutamyltransferase, hepatitis.
Skin and Subcutaneous Tissue Disorders:
Common: Rash. Uncommon: Pruritis, urticaria. Rare: Bullous dermatitis, erythema multiforme. Very Rare: Stevens-Johnson syndrome, toxic epidermal necrolysis.
Musculoskeletal, Connective Tissue and Bone Disorder:
Renal and Urinary Disorders:
Uncommon: Increased blood creatinine. Rare: Interstitial nephritis, renal failure. Very Rare: Increased blood urea nitrogen.
General Disorders and Administration Site Conditions:
Uncommon: Fever, injection site reaction. Rare: Rigors.
Piperacillin therapy has been associated with an increased incidence of fever and rash in cystic fibrosis patients.