Generic Medicine Info
Indications and Dosage
Sexually transmitted diseases, Susceptible infections
Adult: 1.5 g daily in divided doses, up to 3 g/day initially for severe infections.
Child: 30-100 mg/kg/day.

Adult: 2.5 g/day for 1-2 days. Alternatively, 2.5 g on the 1st day followed by 2 g/day on each of 4 subsequent days.
Renal Impairment
Gonorrhoea; Sexually transmitted diseases; Susceptible infections:
CrCl (mL/min) Dosage
10-30 500 mg once daily.
30-60 500 mg bid.
Hypersensitivity, preexisting bone marrow depression or blood dyscrasias, active immunisation. Pregnancy and lactation.
Special Precautions
Renal impairment, Mediterranean form of G6PD, prolonged use. Perform routine periodic blood examination.
Adverse Reactions
Hypersensitivity, GI disturbances, stomatitis, glossitis, encephalopathy, mental depression and headache, ototoxicity. Haemolytic anaemia (Mediterranean form of G6PD), Jarish-Herxheimer reaction. Prolonged use may induce bleeding, peripheral and optic neuritis.
Potentially Fatal: Bone marrow depression; grey baby syndrome, anaphylactic reactions.
Drug Interactions
Potentially Fatal: Drugs that depress bone marrow function.
Mechanism of Action: Thiamphenicol has a broad spectrum of activity similar to chloramphenicol. It is less active than chloramphenicol but it is equally effective and more actively bactericidal against Haemophilus and Neisseria spp. It reversibly binds to 50s subunit of bacterial ribosome blocking the transpeptidation and inhibiting protein synthesis of susceptible bacteria, thus inhibiting cell growth.
Absorption: Peak serum concentrations: 2 hr.
Distribution: Diffuses into the CSF, across the placenta, into breast milk and into the lungs. Protein binding: 10%. Half-life: 2-3 hr, increased in renal impairment.
Metabolism: Undergoes little or no conjugation with glucuronic acid in the liver.
Excretion: Excreted in the urine mainly as unchanged drug (70%); small amount excreted in bile and faeces.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Thiamphenicol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by
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