Thyrozol

Thyrozol

thiamazole

Manufacturer:

PT. Merck Tbk
Concise Prescribing Info
Contents
Thiamazole
Indications/Uses
Dosage/Direction for Use
Adult Conservative treatment of hyperthyroidism: Complete thyroid hormone blockade production Initially 25-40 mg daily. Max daily dose: 40 mg in single dose of 20 mg max. Mild cases: 10 mg twice daily. Severe cases: 20 mg twice daily. Maintenance: Reduce dose to 5-20 mg daily (usually requires additional administration of thyroid hormones). 2nd dosage regimen: Monotherapy Usually 2.5-10 mg daily. Prep for surgery in all forms of hyperthyroidism Attain normal metabolic activity of thyroid gland. Perform surgery as soon as this is achieved. Otherwise, administer supplementary thyroid hormones. In the last 10 days before surgery, iodine may be administered to consolidate the thyroid tissue. Treatment before radioiodine therapy Attain normal metabolic activity of thyroid gland. Higher radioiodine doses may be necessary. Childn Initially 0.3-0.5 mg/kg/day. Maintenance: 0.2-0.3 mg/kg/day. Additional thyroid hormone treatment may be required. Pregnant women 2.5-10 mg daily w/o thyroid hormone. Patient w/ liver damage Low dose as possible.
Administration
Should be taken with food.
Contraindications
Hypersensitivity. Granulocytopenia, cholestasis existing before start of therapy, previous damage to bone marrow after treatment w/ carbimazole or thiamazole.
Special Precautions
Avoid long-term treatment & monitor patients w/ large goitres. Agranulocytosis; monitor blood count. Discontinue treatment if bone marrow damage occurs. Reduce dose once a eurothyroid metabolic condition is achieved. Goitre growth under therapy; rare hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption. Pregnancy & lactation.
Adverse Reactions
Frequently, allergic skin reactions. Nausea, vomiting, epigastric distress, arthralgia, paresthesia, taste loss, alopecia, myalgia, headache, pruritus, drowsiness, neuritis, edema, vertigo, skin pigmentation, jaundice, sialadenopathy & lymphadenopathy.
Drug Interactions
Anticoagulant effect are potentiated by vit K.
MIMS Class
Antithyroid Agents
ATC Classification
H03BB02 - thiamazole ; Belongs to the class of sulfur-containing imidazole derivative agents. Used in the management of thyroid diseases.
Presentation/Packing
Form
Thyrozol FC tab 10 mg
Packing/Price
100's (Rp147,400/pak)
Form
Thyrozol FC tab 5 mg
Packing/Price
100's (Rp104,390/pak)
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