Conservative Treatment of Hyperthyroidism: 2 different dosage regimens are recommended: Complete blocking of thyroid hormone production is achieved with daily doses of thiamazole 25-40 mg.
Initial therapy: To Achieve Normal Metabolic Activity of the Thyroid Gland: Maximum Daily Dose: 40 mg in single doses of maximally thiamazole 20 mg, depending on the severity of the disease. Mild Cases: 2 times 1 tab Thyrozol 10 mg (20 mg). Severe Cases: 2 times 1 tab Thyrozol 20 mg (40 mg).
Initial Therapy of Hyperthyroidism: The previously specified single doses should be taken at regular intervals throughout the day. Maintenance Dose: Can be taken all at once in the morning after breakfast.
After normalization of the thyroid function (generally between weeks 3 and 8), the dose is stepwise reduced in long-term treatment to a maintenance dose of 5-20 mg daily. This dosage usually requires the additional administration of thyroid hormones.
In therapy with Thyrozol alone, the dose depends on metabolic activity which must be checked individually in each patient, paying particular attention to the thyroid-stimulating hormone (TSH) values. The dose is in this case between 2.5 mg and 10 mg daily. Iodine-induced hyperthyroidism may possibly require higher doses.
Preparation for Surgery in All Forms of Hyperthyroidism: Normal metabolic activity of the thyroid gland is attained, as previously described. Surgery should be performed as soon as normal function is achieved. Otherwise, supplementary thyroid hormones must be administered. In the last 10 days before surgery, the surgeon may prefer to administer iodine to consolidate the thyroid tissue.
Treatment Before Radioiodine Therapy: Normal metabolic activity of the thyroid gland is attained, as previously described. Thyrozol reduces the biological half-life of iodine in the thyroid tissue. Therefore, higher radioiodine doses may be necessary.
Children: Initial Dose Depending on the Severity of the Disease: 0.3-0.5 mg/kg body weight daily. Maintenance Dose: 0.2-0.3 mg/kg body weight daily. Additional treatment with thyroid hormone may be required.
Pregnant Women: Dose should be kept as low as possible, 2.5-10 mg daily should be selected and treatment be carried out without the additional administration of thyroid hormone.
In patient with liver damage, the dose should be kept as low as possible.
When preparing patients with hyperthyroidism for surgery, treatment with Thyrozol can be commenced about 3-4 weeks prior to the scheduled time of operation (or earlier in individual cases) and discontinued on the day before surgery.
When used in preparing patients with autonomous adenoma or latent hyperthyroidism for a required exposure to iodine, the duration of treatment with Thyrozol depends on the time the iodine-containing substance is retained in the body.
Patients with considerably enlarged thyroid glands and constriction of the trachea should only undergo short-term treatment with Thyrozol, since long-term administration can result in further thyroid growth, which is associated with the risk of further constriction of the airways. Where necessary, treatment must be monitored particularly carefully.
The treatment is preferably combined with thyroid hormones.
Administration: Take Thyrozol tablets whole with some liquid (eg, ½ glass of water) after meals.
In conservative treatment of hyperthyroidism, therapy with Thyrozol is usually continued over a period of 6 months to 2 years (1 year on average). Statistically, the probability of remission increases with the duration of therapy.