Discontinue treatment if serious hypersensitivity reaction occurs & institute appropriate therapy. May increase risk of infection. Not to be initiated in patients w/ any clinically important active infection until the infection resolves or is adequately treated. Evaluate patients for TB infection prior to initiating treatment. Monitored for signs & symptoms of active TB during & after treatment. Consider completion of all age appropriate immunizations. Avoid use of live vaccines. Avoid during pregnancy. Breast-feeding.