Triprolidine: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Allergic conditions

Adult: 2.5 mg 4-6 hrly. Max: 10 mg daily.
Child: 4 mth to <2 yr 0.313 mg 4-6 hrly. Max: 1.252 mg daily; 2-<4 yr 0.625 mg 4-6 hrly. Max: 2.5 mg daily; 4-<6 yr 0.938 mg 4-6 hrly. Max: 3.744 mg daily; 6-<12 yr 1.25 mg 4-6 hrly. Max: 5 mg daily; ≥12 yr Same as adult dose.

Administration

May be taken with or without food.

Special Precautions

Patient w/ angle-closure glaucoma, prostatic hypertrophy, pyloroduodenal obstruction, stenosing peptic ulcer, bladder or neck obstruction.

Adverse Reactions

Excitability (esp in childn), sedation, dizziness, lassitude, disturbed coordination, muscular weakness, anorexia, nausea, vomiting, diarrhoea, epigastric distress, tachycardia, ECG changes, arrhythmias, dry mouth, urinary retention, impotence, vertigo, visual disturbances, blurred vision, diplopia, tinnitus, acute labyrinthitis, irritability, facial dyskinesia, wheezing, nasal stuffiness, sweating, chills, headache, faintness, paraesthesia. Rarely, leucopenia, thrombocytopenia, haemolytic anaemia.

Patient Counseling Information

This drug may cause dizziness, drowsiness or weakness, if affected, do not drive or operate machinery.

Drug Interactions

Increased sedation w/ CNS depressants (e.g. barbiturates, hypnotics, opioid analgesics, anxiolytics, sedatives and antipsychotics). Increased antimuscarinic side effects w/ other antimuscarinic drugs (e.g. atropine, TCA and MAOI). May mask signs of ototoxicity caused by aminoglycosides.

Food Interaction

Increased sedation w/ alcohol.

Action

Description: Triprolidine blocks the action of endogenous histamine by binding to H₁ receptor. It is useful for the prevention and suppression of the signs and symptoms of allergic rhinitis and other upper resp allergies.
Pharmacokinetics:
Absorption: Time to peak plasma concentration: Approx 2 hr.
Distribution: Distributed into breast milk.
Metabolism: Metabolised hepatically to carboxylated derivative.
Excretion: Via urine, approx 1% as unchanged drug. Elimination half-life: Approx 2 hr.

Chemical Structure

Storage

Store between 15-30°C.

MIMS Class

Antihistamines & Antiallergics

ATC Classification

R06AX07 - triprolidine ; Belongs to the class of other antihistamines for systemic use.

References

Anon. Triprolidine. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 11/07/2016.

Anon. Triprolidine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 11/07/2016.

Buckingham R (ed). Interactions of Antihistamines. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 12/07/2016.

Buckingham R (ed). Triprolidine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 11/07/2016.

McEvoy GK, Snow EK, Miller J et al (eds). Antihistamines General Statement. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 12/07/2016.

Vanahist PD Liquid (GM Pharmaceuticals, Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 21/04/2014.

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