Trizedon OD

Trizedon OD

trimetazidine

Manufacturer:

Servier
Concise Prescribing Info
Contents
Trimetazidine diHCl
Indications/Uses
Adjunctive to established antiangina.
Dosage/Direction for Use
1 cap once daily. Elderly/patient w/ moderate renal impairment (CrCl 30-60 mL/min) Recommended dose: Reduce by ½ (1 tab of 35 mg) in the morning.
Administration
Should be taken with food: Take during breakfast.
Contraindications
Hypersensitivity. Parkinson disease, parkinsonian symptoms, tremors, restless leg syndrome, & other related movement disorders. Severe renal impairment (CrCl <30 mL/min). Use in nursing mothers is generally inadvisable.
Special Precautions
Should not be used as monotherapy. Benefit of the treatment should be assessed after 3 mth, & should be discontinued if there is no treatment response. This drug is not a curative treatment for angina attacks, nor is it indicated as an initial treatment for unstable angina or MI, nor in the pre-hospital phase or during the 1st day of hospitalization. In the event of an angina attack, the coronaropathy should be reevaluated & an adaptation of the treatment considered. Trimetazidine can cause or worsen parkinsonian symptoms (tremor, akinesia, hypertonia), which should be regularly investigated, especially in elderly patients. Falls may occur, related to gait instability or hypotension, in particular in patients taking antihypertensive treatment. This medicine contains an active substance which may give a +ve reaction in doping test in athletes.
Adverse Reactions
Dizziness, headache, abdominal pain, diarrhoea, dyspepsia, nausea, vomiting, rash, pruritus, urticaria, asthenia. Palpitations, extrasystoles, tachycardia, arterial hypotension, orthostatic hypotension that may be associated w/ malaise, dizziness, or a fall, in particular in patients taking antihypertensive treatment, flushing. Parkinsonian symptoms (tremor, akinesia, hypertonia), gait instability, restless leg syndrome, other related movement disorders, usually reversible after treatment discontinuation, sleep disorders (insomnia, drowsiness), vertigo, constipation, AGEP (acute generalized exanthematous pustulosis), angioedema, agranulocytosis, thrombocytopenia, thrombocytopenic purpura, hepatitis.
MIMS Class
Anti-Anginal Drugs
ATC Classification
C01EB15 - trimetazidine ; Belongs to the class of other cardiac preparations.
Presentation/Packing
Form
Trizedon OD PR cap 80 mg
Packing/Price
30's (Rp215,700/pak)
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