Purified protein derivative (PPD) of Mycobacterium tuberculosis
Each mL of Tuberculin PPD RT23 2 TU contains Mycobacterium tuberculosis 0.4 mcg, disodium phosphate dihydrate 7.6 mg, potassium dihydrogen phosphate 1.45 mg, sodium chloride 4.8 mg, potassium dihydroxyquinoline sulphate 100 mcg, polysorbate 80 50 mcg, water for injection 1 mL.
Tuberculin PPD RT23 2 TU is a purified protein derivative prepared from a culture of selected strains of the Mycobacterium tuberculosis.
For Mantoux tuberculin testing to help diagnose if a person has ever been infected with Mycobacterium tuberculosis.
A dose of 0.1 mL of PPD RT23 is injected intracutaneously in the middle-third of the forearm, since a weak reaction near the wrist of elbow. A 1 mL graduated syringe with a short-beveled 25–26 gauge (0.5 x 10 mm) is recommended for administration of the skin test. As the liquid is injected, a small round wheal or papule of 8-10 mm in diameter should be formed, remaining for about 10 minutes.
Reading: During 48–72 hours after injection, an induration, possibly surrounded by area of redness, can be expected in positive reactors. Measure only the induration (skin reaction) about 3 days after the application. The skin reaction can be palpated as flat, uneven, slightly raised induration which should be measured with a clear, flexible, plastic ruler.
A positive reaction to Tuberculin PPD RT23 is defined as an induration having a diameter of 6 mm or more.
Known hypersensitivity to purified protein derivative (PPD) tuberculin.
A transient burning sensation may be experienced immediately after injection, and pain, irritation or discomfort may rarely occur. In individuals who are extremely sensitive to tuberculin, vesicles, bullae, or ulceration may appear at the injection site, and fever or lymph node swelling has been reported.
Vaccination with live attenuated viral vaccine or viral infections such as measles, HIV, or influenza can lower tuberculin reaction for a while. Other diseases, including cancer and sarcoidosis, may decrease sensitivity to tuberculin. Someone who is malnourished and on immunosuppresive treatment may indicate a low reaction to Tuberculin PP RT23 than expected.
Person with active tuberculosis may indicate a reaction of less than 6 mm when the immune system has decreased dramatically due to tuberculosis infection.
One can show a positive Mantoux test results, although not/never been infected with tuberculosis. This can be caused by previous vaccination or prior infection with non-tuberculosis mycobacterium from an environment that does not cause particular disease.
Instructions for Use, Handling & Disposal: It is recommended that vials to be discarded 24 hours after the first dose has been removed.
Preparation of Tuberculin PPD RT23 must be stored at temperatures between +2°C and +8°C protected from light. Expiration date indicated on the label should not be exceeded.
V04CF01 - tuberculin ; Belongs to the class of diagnostic agents used to test for tuberculosis.
Inj (vial) 2 tuberculin unit (TU) x 1.5 mL x 5's.